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Series GSE137897 Query DataSets for GSE137897
Status Public on Mar 28, 2021
Title Transcriptional programming of human epidermis during wound repair and in pressure ulcer at single-cell resolution
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Pressure ulcer (PU) is a chronic non-healing wound caused by continuous pressure of the bodyweight to the skin, which is often seen in spinal cord injury patients and in the bedridden elderly population. In spite of high mortality, the pathophysiology of PU remains poorly understood. We performed single-cell transcriptomic analysis of epidermal cells from PU wound-edges, and compared them with epidermal cells from the intact skin and normal acute wounds (AW) of healthy donors. We identified four keratinocyte clusters, one melanocyte cluster, and one immune cell cluster, and the cellular heterogeneity and gene expression were altered in PU. Our findings provided a high-resolution map of human PU and AW, which are likely to yield new areas for exploration of the pathophysiology of chronic wounds and development of wound therapy.
Overall design In total, 1170 cells with three cell types from nine patients.
Contributor(s)  Landén NX, Deng Q, Li D, Cheng S
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Submission date Sep 23, 2019
Last update date Mar 28, 2021
Contact name Ning Xu
Organization name Karolinska Institutet
Street address CMM L8:02
City Stockholm
ZIP/Postal code 17176
Country Sweden
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (1170)
GSM4091294 H1_0001
GSM4091295 H1_0002
GSM4091296 H1_0003
BioProject PRJNA573734
SRA SRP223028

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE137897_read.txt.gz 11.8 Mb (ftp)(http) TXT
GSE137897_rpkm.txt.gz 49.9 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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