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Series GSE137420 Query DataSets for GSE137420
Status Public on Jan 03, 2020
Title Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-Juvenile Neuronal Ceroid Lipofuscinosis
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We developed an invitro model for Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) using isogenic CLN3 mutated human iPS cell lines and performed transcriptomic profiling of brain organoids derived from these lines to identify transcriptomic changes in the early developing brain model.
Overall design The study consists of mRNA-Seq (6 Control and 6 CLN3 mutant samples) performed in organoids differentiated for 55 days in vitro.
Web link
Contributor(s) Gomez-Giro G, Arias-Fuenzalida J, Jarazo J, Zeuschner D, Ali M, Possemis N, Bolognin S, Halder R, Jäger C, Kuper WE, Zaehres H, del Sol A, van der Putten H, Schöler HR, Schwamborn JC
Citation(s) 31888773
Submission date Sep 13, 2019
Last update date Jan 05, 2020
Contact name Jens Christian Schwamborn
Organization name Luxembourg Center for Systems Biomedicine (University of Luxembourg)
Street address Avenue du Swing, 6
City Belvaux
State/province Luxembourg
ZIP/Postal code 4367
Country Luxembourg
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (12)
GSM4078859 Control_sample_1_mRNA-Seq
GSM4078860 Control_sample_2_mRNA-Seq
GSM4078861 Control_sample_3_mRNA-Seq
BioProject PRJNA565410
SRA SRP221592

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE137420_RAW.tar 32.1 Mb (http)(custom) TAR (of FPKM_TRACKING)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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