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| Status |
Public on Oct 01, 2019 |
| Title |
Enriched environmental conditions modify the gut microbiome composition and fecal markers of inflammation in Parkinson’s disease |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We used a transgenic mouse model overexpressing the complete human SNCA genes modeling familial and sporadic forms of Parkinson’s disease to study whether environmental conditions such as standard versus enriched environment changes the gut microbiome and influences disease progression.
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| Overall design |
Experimental setup consists of control and transgenic mice kept under standard environment and enriched environment conditions, with replicates in each genotype and condition.
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| Contributor(s) |
Singh Y, El Hadidi M, Matthes J, Wassouf Z, Schulze-Hentrich JM, Kohlhofer U, Quintanilla-Martinez de Fend L, Huson D, Riess O, Casadei N |
| Citation(s) |
31749671 |
| |
| Submission date |
Sep 10, 2019 |
| Last update date |
Nov 25, 2019 |
| Contact name |
Jakob Admard |
| Organization name |
Universitätsklinikum Tübingen
|
| Department |
Institut für Medizinische Genetik und Angewandte Genomik
|
| Street address |
Calwerstr. 7
|
| City |
Tübingen |
| ZIP/Postal code |
72076 |
| Country |
Germany |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (19)
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| Relations |
| BioProject |
PRJNA564818 |
| SRA |
SRP221270 |
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