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| Status |
Public on Dec 20, 2019 |
| Title |
Nickel induced transcriptional changes persist post exposure through epigenetic reprograming (RNA-seq dataset) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Nickel is an occupational and environmental toxicant associated with a number of diseases. Our earlier studies showed that Ni-induced alterations to global gene expression persist even after the termination of exposure. A number of earlier studies suggest epigenome as a target of Ni. However, the genome wide dynamics of epigenetic modifications that potentially drive Ni-induced long-term transcriptional changes remain elusive.
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| Overall design |
In this study, we performed a comprehensive analysis of the transcriptome and the epigenome of human epithelial cells during and after termination nickel exposure.
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| Contributor(s) |
Cuddapah S, Zang C, Tanwar VS, Jose C |
| Citation(s) |
31856895 |
| |
| Submission date |
Aug 28, 2019 |
| Last update date |
Jan 08, 2020 |
| Contact name |
Rama Natarajan |
| E-mail(s) |
RNatarajan@coh.org
|
| Organization name |
Beckman Research Institute, City of Hope
|
| Department |
Department of Diabetes Complications and Metabolism
|
| Lab |
Rama Natarajan
|
| Street address |
1500 E Duarte Rd
|
| City |
Duarte |
| State/province |
California |
| ZIP/Postal code |
91010 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE139356 |
Nickel induced transcriptional changes persist post exposure through epigenetic reprograming |
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| Relations |
| BioProject |
PRJNA562688 |
| SRA |
SRP219507 |
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