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Series GSE136337 Query DataSets for GSE136337
Status Public on Aug 31, 2019
Title Identifying a high-risk cellular signature in the multiple myeloma bone marrow microenvironment_2
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The multiple myeloma (MM) tumor microenvironment is thought to influence patient outcomes. To test this, we computationally enumerated relevant cell populations in 436 newly diagnosed MM patients. Unsupervised clustering identified 5 clusters, with patients in Cluster 5 having significantly worse outcomes: 13 fewer months of progression-free survival (P = 0.002) and 8 fewer months of overall survival (P = 0.040). Cell type analysis showed that patients in Cluster 5 had elevated CD8+ T cell and B cell populations, but low granulocyte levels. A granulocyte signature identified an additional 14% of patients with elevated risk but lacking International Staging System stage III or GEP-70 high- risk status
Overall design To determine how the cellular content in the microenvironment contributes to patient outcome RNA extracted from whole bone marrow (WBM) biopsies were analyzed subtracting the signal derived from the malignant plasma cells to focus on the non-tumor cells. A custom algorithm was developed to define and quantitate the impact of cellular subcomponents of the bone marrow (BM) microenvironment on outcome and applied it to a series of WBM trephine biopsies.
Contributor(s) Danziger SA, McConnell M, Gockley J, Young MH, Rosenthal A, Schmitz F, Reiss DJ, Farmer P, Alapat DV, Singh A, Ashby C, Bauer M, Ren Y, Smith K, Couto SS, van Rhee F, Davies F, Zangari M, Petty N, Orlowski RZ, Dhodapkar M, Copeland W, Fox B, Hoering A, Fitch A, Newhall K, Barlogie B, Trotter MW, Hershberg RM, Walker BA, Dervan A, Ratushny AV, Morgan G
Citation(s) 33147277
Submission date Aug 26, 2019
Last update date Nov 25, 2020
Contact name Samuel Danziger
Organization name Celgene
Street address 10300 Campus Point Dr
City La Jolla
State/province CA
ZIP/Postal code 92121
Country USA
Platforms (1)
GPL27143 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [Gene Name Version]
Samples (426)
GSM4046348 AMP.P0462.02.E808.U133Plus.2
GSM4046349 AMP.P1174.05.D586.U133Plus.2
GSM4046350 AMP.P1175.04.D359.U133Plus.2
This SubSeries is part of SuperSeries:
GSE136400 Identifying a high-risk cellular signature in the multiple myeloma bone marrow microenvironment
BioProject PRJNA562264

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE136337_RAW.tar 2.3 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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