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Series GSE136170 Query DataSets for GSE136170
Status Public on Aug 22, 2019
Title Gene expression profiling of wing imaginal disc upon caspase activity inhibition
Organism Drosophila melanogaster
Experiment type Expression profiling by array
Summary Caspase is best known as an enzyme involved in programmed cell death that is conserved in multicellular organisms. In addition to its role in cell death, caspase is emerging as an indispensable enzyme for a wide range of cellular functions, which have recently been termed as Caspase-Dependent non-lethal cellular Processes. We carefully examined the involvement of cell death signaling in tissue size determination using Drosophila wing as a model. We found that executioner caspase activity promoted wing growth independent of apoptosis. To identify the gene expression changes which account for the observed phenomena, we performed microarray analysis of wing imaginal disc upon caspase activity-inhibition by overexpressing p35. The analysis revealed the change in overall transcriptome, but not in the major tissue growth promoting signaling pathways.
Overall design We collected total RNA from wing imaginal discs of wandering 3rd larvae. We used C10 > p35 larvae for caspase activity-inhibited group and C10 > GFP and C10 >LacZ larvae for control groups. N = 5 for each group.
Contributor(s) Shinoda N, Miura M
Citation(s) 31548372
Submission date Aug 21, 2019
Last update date Oct 29, 2019
Contact name Natsuki Shinoda
Phone +81-3-5841-4863
Organization name The University of Tokyo
Department Department of Genetics, Faculty of Pharmaceutical Sciences
Street address 7-3-1 Hongo
City Bunkyo-ku
State/province Tokyo
ZIP/Postal code 1130033
Country Japan
Platforms (1)
GPL17276 Agilent-040871 Drosophila melanogaster 8X60K with Spike (Feature Number version)
Samples (15)
GSM4042073 GFP_1
GSM4042074 GFP_2
GSM4042075 GFP_3
BioProject PRJNA561427

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE136170_RAW.tar 44.8 Mb (http)(custom) TAR (of TXT)
Raw data provided as supplementary file
Processed data included within Sample table

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