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Series GSE136124 Query DataSets for GSE136124
Status Public on Aug 22, 2019
Title Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques
Organism Macaca mulatta
Experiment type Expression profiling by high throughput sequencing
Summary Social experiences are an important predictor of disease susceptibility and survival in humans and other social mammals. Chronic social stress is thought to generate a pro-inflammatory state characterized by elevated antibacterial defenses and reduced investment in antiviral defense. Here, we manipulated long-term social status in female rhesus macaques to show that social subordination alters the gene expression response to ex vivo bacterial and viral challenge. As predicted by current models, bacterial lipopolysaccharide polarizes the immune response such that low status corresponds to higher expression of genes in NF-κB dependent pro-inflammatory pathways and lower expression of genes involved in the antiviral response and type I interferon (IFN) signaling (see Snyder-Mackler et al. Science, 2016 doi:10.1126/science.aah3580 and GSE83304). Here we show that, counter to predictions, low status drives more exaggerated expression of both NF-κB and IFN-associated genes after cells are exposed to the viral mimic Gardiquimod. Status-driven gene expression patterns are not only linked to social status at the time of sampling, but also to social history (i.e., past social status), especially in unstimulated cells. However, for a subset of genes, we observed interaction effects in which females who fell in rank were more strongly affected by current social status than those who climbed the social hierarchy. Together, our results indicate that the effects of social status on immune cell gene expression depend on pathogen exposure, pathogen type, and social history – in support of social experience-mediated biological embedding in adulthood, even in the conventionally memory-less innate immune system.
Overall design mRNA sequencing of Gardiquimod treated whole blood from female rhesus macaques
Contributor(s) Sanz J, Tung J, Barreiro L
Citation(s) 31611381
Submission date Aug 21, 2019
Last update date Oct 13, 2020
Contact name Saideep Gona
Organization name University of Chicago
Street address 1000 E 53rd St
City Chicago
State/province IL - Illinois
ZIP/Postal code 60615
Country USA
Platforms (1)
GPL19129 Illumina HiSeq 2500 (Macaca mulatta)
Samples (42)
GSM4041397 482_Gard_2
GSM4041398 RAa11_Gard_2
GSM4041399 RAc8_Gard_2
BioProject PRJNA561344
SRA SRP218997

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Supplementary file Size Download File type/resource
GSE136124_SGE_Gard_read_counts.txt.gz 880.2 Kb (ftp)(http) TXT
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