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| Status |
Public on Aug 01, 2022 |
| Title |
Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity (RNA-seq: telomerase-deficient vs PGC1aOE) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
PGC1alpha plays an important role in energy metabolism and mitochondrial function in the heart, multiple attempts have failed to upregulate PGC1alpha expression as a therapy, with the underlying mechanism to be answered. We used RNA sequencing to detail the global programme of gene expression in the hearts of third generation of telomerase-deficient mice with or without cardiomyocyte-restricted PGC1alpha overexpression.
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| Overall design |
Heart mRNA profiles of 12-month old telomerase-deficient (G3) and PGC1alpha overexpressed G3 mice were generated by deep sequencing, using Illumina HiSeq.
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| Contributor(s) |
Zhu X, Ju Z |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Aug 05, 2019 |
| Last update date |
Aug 01, 2022 |
| Contact name |
Xudong Zhu |
| E-mail(s) |
xzhu2013@163.com
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| Organization name |
Hangzhou Normal University
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| Street address |
#2318 Yuhangtang Road
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| City |
Hangzhou |
| ZIP/Postal code |
311121 |
| Country |
China |
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| Platforms (1) |
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| Samples (7)
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| This SubSeries is part of SuperSeries: |
| GSE136787 |
Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity |
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| Relations |
| BioProject |
PRJNA558760 |
| SRA |
SRP217504 |
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