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Series GSE134747 Query DataSets for GSE134747
Status Public on Aug 27, 2019
Title Glucocorticoids delay RAF-induced senescence promoted by EGR1
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Analysis of the transcriptional response to treatment with glucocorticoids in human fibroblasts entering oncogene-induced senescence.
 
Overall design BJ-hTert-B-RAF-V600E human cells treated for 24-120 hours with doxycycline to induce B-Raf-V600E expression were treated with clobetasol or compound A for 2 hours before harvest or during the entire time with doxycycline. At least three replicates per sample. Differential expression with clobetasol assessed against control with DMSO (vehicle).
 
Contributor(s) Carvalho C, Courbeyrette R, Derbois C, Olaso R, Deleuze J, Mann C, Thuret J
Citation(s) 31371485
Submission date Jul 23, 2019
Last update date Aug 29, 2019
Contact name Jean-Yves Thuret
Organization name CEA
Street address CEA Saclay Bat 142
City Gif sur Yvette
ZIP/Postal code 91191
Country France
 
Platforms (1)
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
Samples (57)
GSM3965549 hBJV600E_Dox72_Clob2_rep1
GSM3965550 hBJV600E_Dox120_Clob2_rep1
GSM3965551 hBJV600E_EtOH24_CpdA2_rep1
Relations
BioProject PRJNA556258

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE134747_RAW.tar 117.4 Mb (http)(custom) TAR (of IDAT)
GSE134747_non-normalized.txt.gz 28.8 Mb (ftp)(http) TXT
Raw data provided as supplementary file
Processed data included within Sample table
Raw data are available on Series record

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