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| Status |
Public on Aug 21, 2019 |
| Title |
Transcriptomic atlas of thalamic nuclei |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We profiled the transcriptome of 22 thalamic nuclei. Nuclei were retrogradely labeled from their forebrain target areas, microdissected and fluorescent cells pooled. Anterograde tracing was used when identification of nuclear boundaries was ambiguous. We found that thalamic nuclei share a common axis of variance closely linked to the mediolateral spatial axis of thalamus. This axis was enriched in functionally relevant genes such as neurotransmitter receptors and ion channels, and was closely linked to functional and morphological properties of the neurons.
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| Overall design |
Transcriptome profiling of 22 thalamic nuclei, defined via projection labeling
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| |
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| Contributor(s) |
Schulmann A, Phillips JW, Hara E, Wang L, Lemire AL, Nelson SB, Hantman AW |
| Citation(s) |
31527803 |
| |
| Submission date |
Jul 06, 2019 |
| Last update date |
Nov 26, 2019 |
| Contact name |
Anton Schulmann |
| E-mail(s) |
anton.schulmann@nih.gov
|
| Organization name |
NIH/NIMH
|
| Lab |
McMahon
|
| Street address |
35 Convent Dr
|
| City |
Bethesda |
| State/province |
Maryland (MD) |
| ZIP/Postal code |
20814 |
| Country |
USA |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (120)
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| Relations |
| BioProject |
PRJNA552996 |
| SRA |
SRP213359 |
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