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| Status |
Public on Jul 05, 2019 |
| Title |
An Lkb1-Sik axis suppresses tumor growth and controls differentiation [RNA-Seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Background: LKB1 is among the most frequently altered tumor suppressors in lung adenocarcinoma. Despite being implicated in the regulation of a variety of cellular processes, the mechanisms by which LKB1 constrains lung tumor growth and progression remains an area of intense investigation.
Purpose: To determine the extent of overlap in terms of the transcriptomic states arising from either Lkb1 deletion or Sik-targeting within cancer cells isolated from genetically engineered mouse models of oncogenic Kras-driven lung adenocarcinoma
Approach: Cancer cells sorted from mouse lung tumors of defined genotypes were profiled by RNA-seq.
Results: A strong overlap existed between Lkb1-deficient and Sik-targeted cancer cells both at the gene and pathways levels.
Conclusions: Given the strong transcriptional overlap, loss of either Lkb1 or Sik appear to be functionally related.
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| Overall design |
RNA-seq of WT, Lkb1 deletion or Sik-targeted mouse lung cancer cells.
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| |
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| Contributor(s) |
Murray CW, Winslow MM |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 05, 2019 |
| Last update date |
Jul 07, 2019 |
| Contact name |
Christopher Murray |
| Organization name |
Stanford University
|
| Department |
Genetics
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| Lab |
Winslow
|
| Street address |
1291 Welch Rd. B261, Beckman Center
|
| City |
Stanford |
| State/province |
California |
| ZIP/Postal code |
94305 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE133896 |
An Lkb1-Sik axis suppresses tumor growth and controls differentiation |
|
| Relations |
| BioProject |
PRJNA552909 |
| SRA |
SRP213210 |
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