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Series GSE133677 Query DataSets for GSE133677
Status Public on Jul 03, 2019
Title LncRNA NONHSAT113026 represses renal cell carcinoma tumorigenesis through interacting with NF-κB/p50 and SLUG
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We provide evidence that NOAT113026 inhibits renal cancer proliferative and mobility potential by blocking NF-κB/p50 and SLUG expression, which consequently inhibiting the production of oncogenic chemokines and metastasis-promoting genes. Our findings manifest that NOAT113026 may become a critical and feasible target for RCC treatment because of its anti-proliferative and anti-metastatic properties and emerge as an important biomarker for the detection of overall survival and disease-free survival.
 
Overall design We reported a long non-coding RNA (lncRNA), NONHSAT 113026 (NOAT113026), that may play an important role in the pathogenesis of RCC. The expression level of NOAT113026 was estimated by qPCR from 76 pairs of RCC and NT samples. The correlation of NOAT113026 to clinical data of RCC patients was analyzed. NOAT113026 was overexpressed in 786-O and ACHN cell lines by lentivirus-mediated technology, and the oncological behavioral changes of RCC cells were observed, as well as, tumorigenicity in experimental nude mice. Compared to the adjacent tissues, NOAT113026 was obviously downregulated in RCC. Survival analysis showed that the lower the expression level of NOAT113026, the shorter the disease-free survival and overall survival in RCC. Overexpression of NOAT113026 can decrease the ability of cell migration, invasion, proliferation, and colony formation by regulating NF-κB/p50 and SLUG through a mechanism that involves lncRNA-mRNA interactions.
 
Contributor(s) Liu H, Pu Y, Xia Y, Zhang M, Song J, Han J
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Submission date Jul 02, 2019
Last update date Jul 07, 2019
Contact name yan pu
E-mail(s) 15276563356@163.com
Phone 15276563356
Organization name Institute of Cancer Research
Street address Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi 830011, P.R. China
City Urumqi
State/province State...
ZIP/Postal code 830051
Country China
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (6)
GSM3914366 TEST_1
GSM3914367 TEST_2
GSM3914368 TEST_3
Relations
BioProject PRJNA552219
SRA SRP212748

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Supplementary file Size Download File type/resource
GSE133677_Gene_expression.xlsx 33.5 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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