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| Status |
Public on Jul 27, 2020 |
| Title |
KAT7 maintains myeloid leukemogenesis recruits BRD4 to the promoters of target loci to maintain then MLL-AF9 transcriptional programme |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Here we investigate the essentiality of lysine acetyltransferase KAT7 in AMLs driven by the MLL-X fusions. We find that KAT7 activity is required for the recruitment of the MLL-fusion associated adaptor proteins such as BRD4 to gene promoters, which are critical for the maintenance of the MLL-AF9 transcriptional programme. Our findings propose that KAT7 is a plausible therapeutic target for this poor prognosis subtype of AML.
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| Overall design |
Study KAT7 binding and the effects of its knockout on the transcriptome in MOLM13 and OCIAML3 cell lines
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| Contributor(s) |
Au Y, Gu M, DeBraekeleer E, Gozdecka M, Aspris D, Tarumoto Y, Cooper J, Yu J, Ong S, Chen X, Tzelepis K, Huntly BJ, Vassiliou G, Yusa K |
| Citation(s) |
32764680 |
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| Submission date |
Jun 28, 2019 |
| Last update date |
Oct 13, 2020 |
| Contact name |
Muxin Gu |
| E-mail(s) |
muxingu@gmail.com, mg445@cam.ac.uk
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| Phone |
01223767800
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| Organization name |
University of Cambridge
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| Department |
Haematology
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| Lab |
George Vassiliou
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| Street address |
Jeffrey Cheah Biomedical Centre, Puddicombe Way
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| City |
Cambridge |
| ZIP/Postal code |
CB2 0AW |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (33)
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| Relations |
| BioProject |
PRJNA551672 |
| SRA |
SRP212620 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE133516_RAW.tar |
7.5 Mb |
(http)(custom) |
TAR (of BROADPEAK, NARROWPEAK, TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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