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Series GSE133385 Query DataSets for GSE133385
Status Public on Jul 18, 2019
Title Oral JAK/SYK-inhibition (ASN002) suppresses inflammation and improves epidermal barrier markers in atopic dermatitis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We conducted a randomized, double-blind, placebo-controlled trial in adults with moderate-to-severe AD to test the efficacy of JAK/SYK-inhibitor ASN002. ASN002 significantly suppressed key AD inflammatory pathways, corresponding to clinical response, and may be an effective novel therapeutic agent for moderate-to-severe AD.
 
Overall design Patients were randomized to dose escalation of ASN002 20mg, 40mg, 80mg, and placebo groups. Skin biopsies were performed at baseline, day15, and day29. Gene expression studies were conducted using microarray and qRT-PCR, and cellular infiltrates and protein expression were studied by immunohistochemistry.
 
Contributor(s) Pavel AB, Song T, Kim HJ, Ester DD, Krueger JG, Dubin C, Peng X, Xu H, Zhang N, Estrada Y, Denis L, Rao N, Gupta S, Zammit D, Bissonnette R, Guttman-Yassky E
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Submission date Jun 26, 2019
Last update date Jul 20, 2019
Contact name Emma Guttman-Yassky
E-mail(s) emma.guttman@mountsinai.org
Organization name Icahn School of Medicine at Mount Sinai
Department Dermatology
Lab Emma Guttman
Street address One Gustave L. Levy Place
City New York
State/province NY
ZIP/Postal code 10029
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (111)
GSM3907370 28.Placebo.LS.Day29
GSM3907372 25.Placebo.LS.Day29
GSM3907374 22.20mg.LS.Day1
Relations
BioProject PRJNA551301

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE133385_RAW.tar 548.9 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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