 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Sep 10, 2019 |
| Title |
Generating in vivo somatic mouse mosaics with locus-specific, stably-integrated transgenic elements for studies of gene function in development and tumorigenesis [bulk ATAC-seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We report the development and efficiency of a new method to create somatic mosaicism in mice named as mosaic analysis by dual recombinase-mediated cassette exchange. Then we generate, as a proof of concept, a new model for pediatric glioma.
|
| |
|
| Overall design |
Examination by ATAC-seq of a PiggyBack-based mouse model for pediatric brain tumors as compared with normal healthy mouse brain and with the MADR model data at single-cell ATACseq and single-cell RNAseq levels.
|
| |
|
| Contributor(s) |
Kim GB, Rincon-Fernandez-Pacheco D, Saxon D, Yang A, Sabet S, Dutra-Clarke M, Levy R, Watkins A, Park H, Akhtar AA, Linesch P, Kobritz N, Chandra S, Molina J, Gareau D, Hoang K, Tsyporin J, Bannykh S, Santiskulvong C, Wang Y, Tang J, Suva M, Chen B, Danielpour M, Breunig JJ |
| Citation(s) |
31539496 |
| |
| Submission date |
May 29, 2019 |
| Last update date |
Oct 11, 2021 |
| Contact name |
AGCT Core |
| Organization name |
Cedars Sinai Medical Center
|
| Department |
BMS
|
| Street address |
8687 Melrose Ave, PDC B230
|
| City |
West Hollywood |
| State/province |
CA |
| ZIP/Postal code |
90069 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (2) |
|
| This SubSeries is part of SuperSeries: |
| GSE131675 |
Generating in vivo somatic mouse mosaics with locus-specific, stably-integrated transgenic elements for studies of gene function in development and tumorigenesis |
|
| Relations |
| BioProject |
PRJNA545352 |
| SRA |
SRP199799 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE131940_RAW.tar |
336.5 Mb |
(http)(custom) |
TAR (of BW) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
|
|
|
|
 |
