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| Status |
Public on Oct 27, 2021 |
| Title |
Role of transcription factors ONECUT1 (HNF6), GATA6 and NKX6.1 during in vitro pancreatic differentiation of human pluripotent stem cells. |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
We have identified HNF6 as an essential transcription factor for endocrine pancreatic development.
HNF6 binds to and possibly regulates other isletogenesis transcription factors, driving endocrine differentiation.
ChIP sequencing of HNF6 as well as GATA6 and NKX6.1 during in vitro pancreatic differentiation will help to understand the regulatory mechanisms during cell fate decisions.
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| Overall design |
The human embryonic stem cell line CyT49 differentiated to gut tube endoderm and pancreatic progenitor cells were used for chromatin immunoprecipitation.
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| Contributor(s) |
Kwon G, Li Z, Costa IG, Kleger A, Heller S |
| Citation(s) |
34663987 |
| Submission date |
May 28, 2019 |
| Last update date |
Oct 30, 2021 |
| Contact name |
Ivan Costa |
| E-mail(s) |
ivan.costa@rwth-aachen.de
|
| Organization name |
Unikilink RWTH Aachen
|
| Lab |
Computational Biology
|
| Street address |
Pauwelsstraße 19
|
| City |
Aachen |
| ZIP/Postal code |
52074 |
| Country |
Germany |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (7)
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| This SubSeries is part of SuperSeries: |
| GSE131817 |
Role of transcription factor ONECUT1 during in vitro pancreatic differentiation of human pluripotent stem cells |
| GSE167606 |
A transcriptional and open chromatin landscape and the role of ONECUT1 in human pancreas differentiation |
|
| Relations |
| BioProject |
PRJNA545074 |
| SRA |
SRP199617 |
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