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| Status |
Public on Aug 15, 2019 |
| Title |
Gene expression predicts histological severity and reveals distinct molecular profiles of nonalcoholic fatty liver disease |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Transcriptomic analysis of liver biopsies that cover the spectrum of nonalcoholic fatty liver disease reveals genes that are progressively regulated over the course of the disease. This study demonstrates that progressive changes in expression of these genes can be used to approximate the histological grade of a liver biopsy. Furthermore, the relative progression profiles of these disease-responsive genes are shown to be distinct across patient biopsies. This observation suggests that there may be distinct biological processes that drive disease progression across individuals
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| Overall design |
This dataset contains transcriptomic profiles of 78 distinct human liver biopsies. Of these, 6 are histologically normal, and 72 cover the full spectrum of nonalcoholic fatty liver disease (NAFLD activity score 0-6, fibrosis stage 0-4).
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| Contributor(s) |
Hoang SA, Oseini A, Feaver RE, Cole B, Asgharpour A, Vincent R, Siddiqui M, Lawson MJ, Day NC, Taylor JM, Wamhoff BR, Mirshahi F, Contos MJ, Idowu M, Sanyal AJ |
| Citation(s) |
31467298 |
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| Submission date |
May 09, 2019 |
| Last update date |
Dec 06, 2021 |
| Contact name |
Stephen Aurelien Hoang |
| Organization name |
HemoShear Therapeutics
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| Street address |
501 Locust Ave, Suite 301
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| City |
Charlottesville |
| State/province |
Virginia |
| ZIP/Postal code |
22902 |
| Country |
USA |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (78)
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| Relations |
| BioProject |
PRJNA542148 |
| SRA |
SRP197353 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE130970_all_sample_salmon_tximport_TPM_entrez_gene_ID.csv.gz |
5.7 Mb |
(ftp)(http) |
CSV |
| GSE130970_all_sample_salmon_tximport_counts_entrez_gene_ID.csv.gz |
11.0 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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