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Series GSE130874 Query DataSets for GSE130874
Status Public on Jan 01, 2020
Title RNA-Seq analysis of gene expression in 25 cases of canine lymphoma undergoing CHOP chemotherapy
Organism Canis lupus familiaris
Experiment type Expression profiling by high throughput sequencing
Summary Canine lymphoma is the most common hematological cancer in dogs and shares many molecular and clinical characteristics with human Non-Hodgkin lymphoma (NHL). The standard treatment for canine lymphoma is the “CHOP” sequential multiagent chemotherapy protocol consisting of Cyclophosphamide, Doxorubicin (Hydroxydaunorubicin), Vincristine (Oncovin™), and Prednisone. Approximately 70 - 85% of patients treated with CHOP achieve clinical remission. However, duration of remission varies and the majority of dogs eventually relapse. To identify possible biomarkers for patients failing to achieve remission in response to CHOP, we performed RNA-Seq analysis on 25 cases of canine lymphoma taken at the start of their CHOP therapy regime, and determined patient progression free survival (PFS).
Overall design Tumor samples from 25 dogs with lymphoma. Samples were collected prior to treatment with CHOP. There were no replicate or control samples.
Contributor(s) Mee M, Coomber B
Citation(s) 35317846
Submission date May 08, 2019
Last update date Mar 31, 2022
Contact name Miles Mee
Organization name Ontario Institute for Cancer Research
Street address 661 University Ave Suite 510
City Toronto
ZIP/Postal code M5G 0A3
Country Canada
Platforms (1)
GPL22370 Illumina MiSeq (Canis lupus familiaris)
Samples (25)
GSM3755495 Lymphoma, short, 001_S1
GSM3755496 Lymphoma, long, 002_S2
GSM3755497 Lymphoma, long, 003A_S3
BioProject PRJNA541858
SRA SRP197055

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE130874_FPKM_matrix.tsv.gz 3.0 Mb (ftp)(http) TSV
GSE130874_read_count_matrix.tsv.gz 1009.7 Kb (ftp)(http) TSV
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Raw data are available in SRA
Processed data are available on Series record

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