|
| Status |
Public on Apr 16, 2020 |
| Title |
Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
This study demonstrates a specific cooperativity between perturbations in histone methylation and eroded telomeres to destabilize the differentiation of murine embryonic stem cells.
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| |
|
| Overall design |
Murine embryonic stem cells of two different genotypes (WT or Tert-/-) were subjected to differentiation, and treated with compounds that modulated histone H3K27 tri-methylation to assess their impact upon the differentiation response
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| |
|
| Contributor(s) |
Criqui M, Qamra A, Chu T, Sharma M, Tsao J, Henry DA, Barsyte-Lovejoy D, Arrowsmith CH, Winegarden N, Lupien M, Harrington L |
| Citation(s) |
32297856 |
|
https://elifesciences.org/articles/47333
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| |
| Submission date |
May 06, 2019 |
| Last update date |
May 12, 2020 |
| Contact name |
Lea Harrington |
| Organization name |
University of Montreal
|
| Department |
Department of Medicine
|
| Lab |
Institute for Research in Immunology and Cancer
|
| Street address |
2950 chemin de Polytechnique, Pavillon Marcelle-Coutu
|
| City |
Montreal |
| State/province |
Quebec |
| ZIP/Postal code |
H3T1J4 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (56)
|
|
| Relations |
| BioProject |
PRJNA541428 |
| SRA |
SRP195732 |
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