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| Status |
Public on Mar 19, 2019 |
| Title |
Human cochlear gene expression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Transcriptome analysis of human inner ear tissue
Hearing loss is common and caused by a wide range of molecular and cellular pathologies. Current diagnosis of hearing loss depends of a combination of physiologic testing, patient history and in some cases genetic testing. Currently no biopsy or equivalent procedure exists to diagnose inner ear disorders. The goal of this study was to determine if miRNAs could be identified in human perilymph potentially leading to the development of biomarkers for inner ear disease. Analysis of miRNAs was carried out by evaluating miRNA targets in a cochlear transcriptome library (GSE128505) derived from human inner ear tissue harvested during surgery in which the inner ear is removed.
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| Overall design |
Basilar membrane, cochlear lateral wall and modiolous harvested at time of transcochlear approach to skull base meningioma
Total RNA isolated and analyzed with Affymetrix Human Transcriptome 2.0 array; Data was processed with the Affymetrix console
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| Contributor(s) |
Hinrich S |
| Citation(s) |
30971872, 34220670 |
| |
| Submission date |
Mar 18, 2019 |
| Last update date |
Jul 08, 2021 |
| Contact name |
Hinrich Staecker |
| E-mail(s) |
hstaecker@kumc.edu
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| Organization name |
University of Kansas School of Medicine
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| Department |
Otolaryngology Head and Neck Surgery
|
| Street address |
Rainbow Blvd.
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| City |
Kansas City |
| State/province |
KS |
| ZIP/Postal code |
66160 |
| Country |
USA |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (1) |
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| Relations |
| BioProject |
PRJNA527880 |
