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| Status |
Public on May 13, 2019 |
| Title |
Genomic DNA methylation distinguishes human FCD subtypes |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
Focal Cortical Dysplasia (FCD) is a major cause of drug-resistant focal epilepsy in children and the clinico-pathological classification remains a challenging issue in daily practice. With the recent progress in DNA methylation based classification of human brain tumors we examined, whether genomic DNA methylation and gene expression analysis can be used to also distinguish human FCD subtype
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| Overall design |
DNA methylomes and transcriptomes were generated from massive parallel sequencing in 15 surgical FCD specimens, matched with 5 epilepsy (TLE-HS) and 6 non-epilepsy controls.
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| Contributor(s) |
Kobow K, Ziemann M, Harikrishnan KN, Khurana I, Mühlebner A, Feucht M, Hainfellner JA, Czech T, Aronica E, Pieper T, Holthausen H, Kudernatsch M, Hamer H, Kasper BS, Rössler K, Conti V, Guerrini R, Coras R, Blümcke I, El-Osta A, Kaspi A |
| Citation(s) |
31074842 |
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| Submission date |
Mar 14, 2019 |
| Last update date |
May 13, 2019 |
| Contact name |
Assam El-Osta |
| Organization name |
Baker Heart and Diabetes Institute
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| Lab |
Human Epigenetics
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| Street address |
75 Commercial Road
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| City |
Melbourne |
| ZIP/Postal code |
3004 |
| Country |
Australia |
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| Platforms (1) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
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| Samples (53)
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| This SubSeries is part of SuperSeries: |
| GSE128301 |
Transcriptome and Genomic DNA methylation distinguishes human FCD subtypes |
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| Relations |
| BioProject |
PRJNA527061 |
| SRA |
SRP188421 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE128299_MM_MACSvINPUT_drop_17_18_600bpsubwin_2019.mx.txt.gz |
31.4 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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