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| Status |
Public on Mar 15, 2019 |
| Title |
A homeostasis hypothesis of avian influenza resistance in chickens |
| Organism |
Gallus gallus |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
Avian influenza caused significant damages to the poultry industry, efforts have been made to reveal the disease mechanisms as well as mechanisms of disease resistance. Here, by investigating two chicken breeds with distinct responses to avian influenza virus (AIV), Leghorn GB2 and Fayoumi M43, we compared their differences in genome, methylation and transcriptome. Except for MX1 involved direct acting antiviral mechanism, we found that in both methylation and transcriptome levels the more AIV resistant breed Fayoumi showed less variations compared to White Leghorn after AIV challenging. Fayoumi also showed better consistency between the changes in methylation and changes in transcriptome level. Our results suggested a homeostasis hypothesis of avian influenza resistance, with Fayoumi better maintaining homeostasis both in epigenetic and gene expression levels.
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| Overall design |
DNA methylation profiles of two highly inbred chicken lines, Leghorn and Fayoumi, which were generated by deep sequencing, using Illumina GAII.
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| Contributor(s) |
An J, Li J |
| Citation(s) |
31319606 |
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| Submission date |
Mar 08, 2019 |
| Last update date |
Aug 27, 2019 |
| Contact name |
Jing An |
| Organization name |
Universite Paris Saclay
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| Street address |
630 Rue Noetzlin
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| City |
Paris |
| ZIP/Postal code |
91190 |
| Country |
France |
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| Platforms (1) |
| GPL9385 |
Illumina Genome Analyzer II (Gallus gallus) |
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| Samples (8)
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| GSM3671352 |
Leghorn biological replicate1 individual injected with avian influenza virus [LI1-B] |
| GSM3671353 |
Leghorn biological replicate1 individual injected with avian influenza virus [LI1-C] |
| GSM3671354 |
Leghorn biological replicate2 individual injected with avian influenza virus [LI2-A] |
| GSM3671355 |
Leghorn biological replicate2 individual injected with avian influenza virus [LI2-B] |
| GSM3671356 |
Fayoumi biological replicate1 individual injected with avian inluenza virus [FI1_A] |
| GSM3671357 |
Fayoumi biological replicate1 individual injected with avian influenza virus [FI1_B] |
| GSM3671358 |
Fayoumi biological replicate2 individual injected with avian influenza virus [FI2_A] |
| GSM3671359 |
Fayoumi biological replicate2 individual injected with avian influenza virus [FI2_C] |
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| Relations |
| BioProject |
PRJNA527115 |
| SRA |
SRP188450 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE128053_RAW.tar |
1007.8 Mb |
(http)(custom) |
TAR (of COV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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