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Series GSE127816 Query DataSets for GSE127816
Status Public on Jul 20, 2019
Title Effects of small molecules targeting the androgen receptor DNA-binding domain on prostate cancer cell transcriptome
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Prostate cancer is a leading cause of cancer related death among men. Current Androgen Receptor (AR) antagonists often target the ligand binding domain (LBD). However, occurrence of resistance to drugs targeting the LBD is common due to emergence of mutations in the LBD or constitutively active variants that lack the LBD itself. Two novel small molecules, VPC-17005 and VPC-14449 targeting the DNA-binding domain have been developed and published previously. In this study, LNCaP cells were treated with one of these drugs or the well-established AR antagonist Enzalutamide, and the transcriptomic changes have been determined using RNA-seq analysis.
Overall design Polyadenylated RNA profiles of LNCaP cells treated with treated with dihydrotestosterone (DHT) plus either DMSO (Control), Enzalutamide, VPC-17005, or VPC-14449, in three biological replicates, obtained using BGISeq500 platform.
Contributor(s) Cavga AD, Lack NA
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Submission date Mar 04, 2019
Last update date Jul 20, 2019
Contact name Ayse Derya Cavga
Organization name Koc University
Street address Rumelifeneri Yolu, Sariyer
City Istanbul
ZIP/Postal code 34450
Country Turkey
Platforms (1)
GPL23227 BGISEQ-500 (Homo sapiens)
Samples (12)
GSM3639309 01_DMSO_DHT_rep1
GSM3639310 01_DMSO_DHT_rep2
GSM3639311 01_DMSO_DHT_rep3
BioProject PRJNA525448
SRA SRP187473

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SOFT formatted family file(s) SOFTHelp
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Supplementary file Size Download File type/resource
GSE127816_DESeq2results_PCaDrugs_vsDHT.xlsx 7.7 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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