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Series GSE127554 Query DataSets for GSE127554
Status Public on Nov 15, 2019
Title In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Recent evidence has determined that the conserved X chromosome “mega-structures” controlled by the Firre and Dxz4 alleles are not required for X chromosome inactivation (XCI) in cell lines. Here we determined the in vivo contribution of these alleles individually and in combination and found that mutant mice are viable, fertile and show no defect in random or imprinted XCI. However, the lack of these elements results in many dysregulated genes on autosomes in an organ-specific manner, suggesting that these X-linked loci are involved in autosomal gene regulation rather than XCI biology.
Overall design RNA-seq from Firre and/or Dxz4 deletion mouse strains (embryonic, extraembryonic and adult organs)
Contributor(s) Andergassen D, Meissner A, Rinn JL
Citation(s) 31738164
Submission date Feb 28, 2019
Last update date Dec 05, 2022
Contact name Daniel Andergassen
Organization name Technical University Munich
Lab Andergassen
Street address Biedersteiner Straße 29
City Munich
ZIP/Postal code 80802
Country Germany
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (182)
GSM3636580 Br_DFxDF_--_1
GSM3636581 Br_DFxDF_--_2
GSM3636582 Br_DFxDF_--_3
BioProject PRJNA525066
SRA SRP187189

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Supplementary file Size Download File type/resource
GSE127554_RAW.tar 699.4 Mb (http)(custom) TAR (of BW)
GSE127554_bigwig_files.tar.gz 14.3 Gb (ftp)(http) TAR
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