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Series GSE126733 Query DataSets for GSE126733
Status Public on Aug 22, 2019
Title Genomic profiling of MondoA and H3K27ac in primary human skeletal myotubes
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary It is well known that insulin resistance in the obese state is associated with accumulation of neutral lipid in extra-adipose tissues. This phenomenon is particularly well-documented in skeletal muscle. The mechanistic underpinnings of this linkage are not fully understood. To define direct MondoA target genes, we performed MondoA ChiP sequencing in human myotubes.
 
Overall design ChiP seq was performed in differentiated primary human skeletal myotubes. These cells were transfected with siRNA of control or MondoA. Two biological replicates for each condition were included.
 
Contributor(s) Ahn B, Wan S, Won K, Kelly DP
Citation(s) 31287806
Submission date Feb 19, 2019
Last update date Aug 22, 2019
Contact name Byungyong Ahn
E-mail(s) byahn@pennmedicine.upenn.edu
Phone 2158982374
Organization name University of Pennsylvania
Department Penn Cardiovascular Institute
Street address 3400 Civic Center Blvd Bldg 421
City Philadelphia
State/province Pennsylvania
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (3)
GSM3611921 MondoA_Control_ChIP-seq
GSM3611922 MondoA_KD_ChIP-seq
GSM3611923 H3K27ac_Control_ChIP-seq
This SubSeries is part of SuperSeries:
GSE126767 MondoA Links Muscle Lipid Accumulation and Insulin Resistance Driven by Nutrient Overload
Relations
BioProject PRJNA523145
SRA SRP186250

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE126733_RAW.tar 1.1 Gb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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