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Series GSE12667 Query DataSets for GSE12667
Status Public on Sep 05, 2008
Title Discovery of somatic mutations in lung adenocarcinomas
Organism Homo sapiens
Experiment type Expression profiling by array
Summary This was a collaborative study to discover somatic mutations in 188 lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high frequencies and thus are likely to play a role in carcinogenesis. The observed mutational profiles correlate with clinical features, smoking status, and DNA repair defects. These results are complemented by data integration including SNP array data and gene expression array data (deposited here). Our findings shed further light on several key signaling pathways involved in lung adenocarcinoma, and suggest new molecular targets for treatment.
 
Overall design The overall design strategy was to sequence a large number of candidate cancer genes from patients diagnosed with adenocarcinoma with the objective of characterizing cancer genomes. For microarray analysis, a subset of 75 RNAs from a corresponding set of 188 lung adenocarcinomas DNAs were resequenced across 623 genes.
 
Contributor(s) Watson M, Wilson R, Ding L
Citation(s) 18948947
Submission date Sep 04, 2008
Last update date Mar 25, 2019
Contact name Rekha Meyer
E-mail(s) rmeyer@pathbox.wustl.edu
Phone 314 362 8853
Organization name Washington University School of Medicine
Street address 4320 Forest Park Av
City St Louis
State/province MO
ZIP/Postal code 63128
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (75)
GSM318073 22049
GSM318074 22050
GSM318075 22051
Relations
BioProject PRJNA112737

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12667_RAW.tar 328.8 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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