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| Status |
Public on Feb 13, 2019 |
| Title |
Gene expression analysis of a subcutaneous MV4;11 tumor treated with curaxin CBL0137. |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The aim of this experiment was to identify how CBL0137 decreased tumor growth in a subcutaneous MV4;11 xenograft model by investigating the gene expression changes induced upon treatment.
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| Overall design |
> 1 million MV4;11 cells were inoculated subcutaneously in the flank of NOD/SCID (NOD/SCID NOD.CB17-Prkdcscid/SzJ) mice. When tumors measured around 100 mm3, mice were treated with CBL0137 (70 mg/kg CBL0137 intravenously) on day 0 and day 8. Tumors were harvested 24h post last injection on day 8. Tumors were also harvested from untreated mice. Tumors were flash frozen in liquid nitrogen and RNA was isolated.
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| Contributor(s) |
Gurova KV, Neznanov N, Mayoh C, Somers K, Henderson MJ |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Feb 12, 2019 |
| Last update date |
Feb 13, 2019 |
| Contact name |
Michelle Haber |
| E-mail(s) |
mhaber@ccia.org.au
|
| Organization name |
Children's Cancer Institute
|
| Street address |
Lowy Cancer Research Centre, PO BOX 81
|
| City |
Randwick |
| State/province |
NSW |
| ZIP/Postal code |
2031 |
| Country |
Australia |
| |
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| Platforms (1) |
| GPL22245 |
Illumina HiSeq 2500 (Homo sapiens; Mus musculus) |
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| Samples (4)
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| GSM3601945 |
MV4;11 70 mg/kg CBL0137 treated replicate 2 |
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| Relations |
| BioProject |
PRJNA521944 |
| SRA |
SRP185693 |
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