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Series GSE126289 Query DataSets for GSE126289
Status Public on Aug 22, 2019
Title RNA Sequencing Analysis of macrophage and CD4+T cells from Wild Type and Gsdmd-/- mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We identified that GSDMD was required for the pathogenesis of EAE, and GSDMD deficiency in peripheral myeloid cells impaired the infiltration of immune cells into the CNS , leading to the suppression of neuroinflammation and demyelination.The purpose of this experiment was to identify how GSDMD induces EAE.
 
Overall design Macrophage and CD4+T cells mRNA profiles of wild type (WT) and Gsdmd-/- mice with experimental autoimmune encephalomyelitis were generated by deep sequencing, in triplicate, using BGISEQ-500
 
Contributor(s) Yang S, Wu Y, Li S
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Feb 08, 2019
Last update date Aug 25, 2019
Contact name Yuqing Wu
E-mail(s) iwuyuqing@126.com
Organization name Nanjing Medical University
Street address 101 Longmian Road
City Nanjing
ZIP/Postal code 211166
Country China
 
Platforms (1)
GPL23479 BGISEQ-500 (Mus musculus)
Samples (12)
GSM3595728 CD4WT1
GSM3595729 CD4WT2
GSM3595730 CD4WT3
Relations
BioProject PRJNA521482
SRA SRP184668

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE126289_RAW.tar 1.1 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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