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Series GSE126078 Query DataSets for GSE126078
Status Public on Jul 17, 2019
Title Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The widespread and long-term use of potent therapies designed to repress androgen receptor (AR) signaling is changing the molecular and phenotypic landscapes of prostate cancer. We conducted molecular profiling of metastatic castration-resistant prostate cancer (mCRPC) patient specimens and patient-derived xenograft models and identified five distinct mCRPC phenotypes. Herein, we characterize an AR-low phenotype that has low AR expression with concomitant decreases in a subset of AR regulated genes, and an amphicrine phenotype that has both AR and neuroendocrine activity in the same cell. Furthermore, our data highlight an emerging squamous cell mCRPC phenotype.
Overall design RNA sequencing of human prostate tumor cell lines, patient-derived xenograft (PDX) models, and metastatic castration-resistant prostate cancer (mCRPC) tumors using Illumina TruSeq Library prep and sequenced on Illumina HiSeq 2500.

This series includes re-analyzed samples from GSE118435.
Contributor(s) Labrecque MP, Coleman IM, Brown LG, True LD, Kollath L, Lakely B, Nguyen HM, Yang YC, Kaipainen AH, Coleman RT, Higano CS, Yu EY, Cheng HH, Mostaghel EA, Montgomery B, Schweizer MT, Hsieh AC, Lin DW, Corey E, Nelson PS, Morrissey C
Citation(s) 31361600
Submission date Feb 04, 2019
Last update date Aug 23, 2019
Contact name Ilsa Coleman
Phone 206-667-1703
Organization name Fred Hutchinson Cancer Research Center
Department Human Biology
Lab Peter Nelson
Street address 1100 Fairview Ave N, E2-112
City Seattle
State/province WA
ZIP/Postal code 98109
Country USA
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (153)
GSM3590965 C42B_siNCT_1
GSM3590966 C42B-siNCT_2
GSM3590967 C42B_siREST_1
BioProject PRJNA520923
SRA SRP183532

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE126078_RAW.tar 105.7 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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