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Series GSE125483 Query DataSets for GSE125483
Status Public on Jul 15, 2019
Title Conservation, acquisition, and functional impact of sex-biased gene expression in mammalian tissues
Organisms Macaca fascicularis; Canis lupus familiaris; Mus musculus; Rattus norvegicus
Experiment type Expression profiling by high throughput sequencing
Summary Sex differences are widespread in human health and disease, which are frequently modeled in other mammalian species. However, the extent to which molecular sex differences are conserved across both tissues and species remains unclear. We conducted a 12-tissue, five-species survey of sex differences in gene expression using both publicly available (human) and newly generated (cynomolgus macaque, mouse, rat, and dog) RNA sequencing data. In each of the tissues assessed, we identified between 128 and 805 genes with conserved sex-biased expression. However, most sex bias in gene expression (~77%) – both female and male – has arisen since the last common ancestor of boroeutherian mammals, likely facilitated by reduced selective constraint. Evolutionary gains and losses of regulation by sex-biased transcription factors drove a significant fraction (~27%) of lineage-specific changes in sex bias. Our study suggests caution in the use of other species as models of human sex differences, and that similar selective pressures have driven sex-biased gene expression both within and outside the reproductive tract.
Overall design Tissue transcriptomes from 12 tissues and 4 species, 3 males and 3 females per species (before removal of outliers) were sequenced and compared for sex differences
Contributor(s) Naqvi S, Page DC
Citation(s) 31320509
Submission date Jan 22, 2019
Last update date Aug 08, 2019
Contact name Sahin Naqvi
Organization name Whitehead Institute
Lab Page
Street address 455 Main St
City Cambridge
State/province MA
ZIP/Postal code 02142
Country USA
Platforms (4)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
GPL18694 Illumina HiSeq 2500 (Rattus norvegicus)
GPL20302 Illumina HiSeq 2500 (Macaca fascicularis)
Samples (307)
GSM3575137 L16_1321_Cyno_1_Adipose
GSM3575138 L16_1055_Cyno_1_Adrenal
GSM3575139 L16_1603_Cyno_1_Brain
BioProject PRJNA516470
SRA SRP181218

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE125483_cyno.salmon.tximport.counts.txt.gz 21.1 Mb (ftp)(http) TXT
GSE125483_cyno.salmon.tximport.tpm.txt.gz 10.7 Mb (ftp)(http) TXT
GSE125483_cyno.stringtie.gtf.gz 14.3 Mb (ftp)(http) GTF
GSE125483_cyno.tx2geneid.txt.gz 851.6 Kb (ftp)(http) TXT
GSE125483_dog.salmon.tximport.counts.txt.gz 18.9 Mb (ftp)(http) TXT
GSE125483_dog.salmon.tximport.tpm.txt.gz 9.4 Mb (ftp)(http) TXT
GSE125483_dog.stringtie.gtf.gz 14.4 Mb (ftp)(http) GTF
GSE125483_dog.tx2geneid.txt.gz 811.4 Kb (ftp)(http) TXT
GSE125483_mouse.salmon.tximport.counts.txt.gz 22.4 Mb (ftp)(http) TXT
GSE125483_mouse.salmon.tximport.tpm.txt.gz 10.9 Mb (ftp)(http) TXT
GSE125483_mouse.stringtie.gtf.gz 14.7 Mb (ftp)(http) GTF
GSE125483_mouse.tx2geneid.txt.gz 1.1 Mb (ftp)(http) TXT
GSE125483_rat.salmon.tximport.counts.txt.gz 18.4 Mb (ftp)(http) TXT
GSE125483_rat.salmon.tximport.tpm.txt.gz 9.2 Mb (ftp)(http) TXT
GSE125483_rat.stringtie.gtf.gz 12.2 Mb (ftp)(http) GTF
GSE125483_rat.tx2geneid.txt.gz 741.4 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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