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Series GSE124731 Query DataSets for GSE124731
Status Public on Jan 08, 2019
Title Transcriptomic characterization of human innate T cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We performed low input RNA-seq and single-cell RNA-seq to transcriptionally characterize four human innate T cell (ITCs) subsets, namely iNKT, MAIT, Vδ1 expressing γδ T cells, and Vδ2 expressing γδ T cells. We compared ITCs to CD4+ T and CD8+ T cells, representing the adaptive compartment, and to Natural Killer (NK) cells, representing the innate compartment.
Overall design Low input RNA-seq was performed for 6 healthy individuals, with two replicates per cell type. Single-cell RNA-seq was performed for 2 healthy individuals, obtaining a total of 2,036 high quality cells.
Submitter note: Because these are human data, we are submitting our raw data to dbGAP.
Contributor(s) Gutierrez-Arcelus M, Brennan PJ, Raychaudhuri S
Citation(s) 30737409
NIH grant(s)
Grant ID Grant title Affiliation Name
U01 GM092691 Genetic predictors of response to anti-TNF therapy in rheumatoid arthritis BRIGHAM AND WOMEN'S HOSPITAL Soumya Raychaudhuri
Submission date Jan 07, 2019
Last update date Mar 26, 2019
Contact name Maria Gutierrez-Arcelus
Organization name Brigham and Women's Hospital, Harvard Medical School
Department Medicine
Street address 77 Avenue Louis Pasteur
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (80)
GSM3544524 low_input_rnaseq_CD4_IGTB107_45
GSM3544525 low_input_rnaseq_CD4_IGTB107_46
GSM3544526 low_input_rnaseq_CD4_IGTB187_74
BioProject PRJNA513294

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE124731_low_input_rnaseq_gene_counts.txt.gz 5.5 Mb (ftp)(http) TXT
GSE124731_low_input_rnaseq_gene_normalized.txt.gz 10.8 Mb (ftp)(http) TXT
GSE124731_low_input_rnaseq_meta_data.txt.gz 2.0 Kb (ftp)(http) TXT
GSE124731_single_cell_rnaseq_gene_counts.txt.gz 2.7 Mb (ftp)(http) TXT
GSE124731_single_cell_rnaseq_gene_normalized.txt.gz 16.4 Mb (ftp)(http) TXT
GSE124731_single_cell_rnaseq_meta_data.txt.gz 95.5 Kb (ftp)(http) TXT
Processed data are available on Series record
Raw data not provided for this record

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