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Series GSE124530 Query DataSets for GSE124530
Status Public on Jan 11, 2019
Title Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We perform a large-scale RNA sequencing study to experimentally identify genes that are downregulated by 25 miRNAs. This RNA-seq dataset is combined with public miRNA target binding data to systematically identify miRNA targeting features that are characteristic of both miRNA binding and target downregulation. By integrating these common features in a machine learning framework, we develop and validate an improved computational model for genome-wide miRNA target prediction. All prediction data can be accessed at miRDB (http://mirdb.org).
 
Overall design RNA-seq to identify transcript targets that are downregulated by overexpression of 25 individual miRNAs.
 
Contributor(s) Wang X, Liu W
Citation(s) 30670076
Submission date Jan 01, 2019
Last update date Jan 24, 2019
Contact name Xiaowei Wang
Organization name Washington University in St. Louis
Street address 4511 Forest Park Ave
City St. Louis
State/province MO
ZIP/Postal code 63108
Country USA
 
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (52)
GSM3535869 hsa-let-7c-5p rep 1
GSM3535870 hsa-let-7c-5p rep 2
GSM3535871 hsa-miR-107 rep 1
Relations
BioProject PRJNA512378
SRA SRP174973

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE124530_Normalized_data_rep_1.txt.gz 1020.0 Kb (ftp)(http) TXT
GSE124530_Normalized_data_rep_2.txt.gz 1009.1 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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