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Series GSE12453 Query DataSets for GSE12453
Status Public on Oct 01, 2008
Title Origin and pathogenesis of lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly due to the technical challenge of analyzing its rare neoplastic L&H cells, which are dispersed in an abundant non-neoplastic cellular microenvironment. We performed a genome-wide expression study of microdissected lymphocytic and histiocytic (L&H) lymphoma cells in comparison to normal and other malignant B cells, which indicates a relationship of L&H cells to and/or origin from germinal center B cells at transition to memory B cells. L&H cells show a surprisingly high similarity to the tumor cells of T cell-rich B cell lymphoma and classical Hodgkin lymphoma, a partial loss of their B cell phenotype and deregulation of many apoptosis-regulators and putative oncogenes. Importantly, L&H cells are characterized by constitutive NF-κB activity and aberrant ERK signaling. Thus, these findings shed new light on the nature of L&H cells, revealed several novel pathogenetic mechanisms in NLPHL, and may help in differential diagnosis and lead to novel therapeutic strategies.
Overall design Analysis of differential gene expression in primary human lymphoma cells of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) in comparison with primary lymphoma cells of classical Hodgkin lymphoma cells and other B-non-Hodgkin lymphoma (B-NHL) samples and subsets of non-neoplastic B lymphocytes isolated from blood or tonsils. 67 gene expression profiles were analysed.
Contributor(s) Brune V, Tiacci E, Pfeil I, Döring C, Eckerle S, van Noesel C, Klapper W, Falini B, von Heydebreck A, Metzler D, Bräuninger A, Hansmann M, Küppers R
Citation(s) 18794340, 24376854, 29889102
Submission date Aug 14, 2008
Last update date Mar 25, 2019
Contact name Ralf Küppers
Phone 0049 201 723 3384
Fax 0049 201 723 3386
Organization name University of Duisburg-Essen, Medical School
Department Institute for Cell Biology (Tumor Research)
Street address Virchowstr. 173

City Essen
ZIP/Postal code 45122
Country Germany
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (67)
GSM312811 cHL1
GSM312812 cHL2
GSM312813 cHL3
BioProject PRJNA113011

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Supplementary file Size Download File type/resource
GSE12453_RAW.tar 468.3 Mb (http)(custom) TAR (of CEL)
SRA Run SelectorHelp
Raw data provided as supplementary file
Processed data included within Sample table

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