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Series GSE124226 Query DataSets for GSE124226
Status Public on Jan 24, 2019
Title Gene Expression Data of Adipose Stem Cells from Normal-Weight Polycystic Ovary Syndrome Women vs. Controls
Organism Homo sapiens
Experiment type Expression profiling by array
Summary In vitro studies of subcutaneous (SC) abdominal adipose stem cells (ASC) from women with polycystic ovary syndrome (PCOS) show altered ASC commitment to preadipocytes and differentiation to mature adipocytes related to hyperandrogenism.
The goal of the study is to use microarrays to examine whether SC abdominal ASC gene expression are altered in normal-weight PCOS women and correlated with hyperandrogenemia and/or insulin resistance, which are prevalent clinical pathologies of PCOS.
 
Overall design ASCs were isolated from SC adipose tissue following SC abdominal biopsy in 4 PCOS women and 4 age and BMI matched controls for gene expression comparison. First generation of stem cells were cultured until cells reached confluency and isolated for RNA extraction and hybridization on Affymetrix microarrays.

Grant#: P50 HD071836
Title: Androgen excess as a mechanism for adipogenic dysfunction in PCOS women
Period: 2018-2022
 
Contributor(s) Phan JD, Leung KL, Ding X, Li X, Chazenbalk GD
Citation(s) 30649347
Submission date Dec 20, 2018
Last update date Mar 25, 2019
Contact name Greogorio Chazenbalk
E-mail(s) gchazenbalk@mednet.ucla.edu
Phone 1-818-599-4175
Organization name University of California, Los Angeles
Department Obstetrics and Gynecology
Street address 10833 Le Conte Ave
City Los Angeles
State/province California
ZIP/Postal code 90095
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (8)
GSM3526020 ASC-3004-control
GSM3526021 ASC-3006-PCOS
GSM3526022 ASC-3010-PCOS
Relations
BioProject PRJNA516631

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Supplementary file Size Download File type/resource
GSE124226_RAW.tar 38.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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