|
| Status |
Public on Aug 22, 2019 |
| Title |
The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Mammals evolved in the face of fluctuating food availability. How the immune system adapts to transient nutritional stress remains poorly understood. Here, we show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation. This response was coordinated by glucocorticoids and associated with a profound remodeling of the BM compartment, which included an increase in T cell homing factors, erythropoiesis, and adipogenesis. Adipocytes and CXCR4-CXCL12 and S1P-S1P1R interactions contributed to enhanced T cell accumulation in BM during DR. Memory T cell homing to BM during DR was associated with enhanced protection against infections and tumors. Together, this work uncovers a fundamental host strategy to sustain and optimize immunological memory during nutritional challenges that involved a temporal and spatial reorganization of the memory pool within ‘‘safe haven’’ compartments.
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| |
|
| Overall design |
Examiniation of T cells and whole tissue of dietary restriction versus normal condition with RNA-seq
|
| |
|
| Contributor(s) |
Collins N, Han S, Enamorado M, Link VM, Belkaid Y |
| Citation(s) |
31442402 |
| |
| Submission date |
Dec 18, 2018 |
| Last update date |
Jun 07, 2022 |
| Contact name |
Verena Link |
| E-mail(s) |
verena.link@nih.gov
|
| Organization name |
NIH
|
| Department |
NIAID
|
| Street address |
4 Memorial Drive
|
| City |
Bethesda |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (20)
|
|
| Relations |
| BioProject |
PRJNA510644 |
| SRA |
SRP173822 |
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