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Series GSE123582 Query DataSets for GSE123582
Status Public on Apr 16, 2019
Title Intergenerational transmission of the positive effects of physical exercise on brain and cognition
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Parental moderate exercise induces positive effects on sedentary litter’s behavior, and on hippocampal gene expression, adult neurogenesis and mitochondrial activation
Overall design A first set of animals was assigned to 2 groups: 'Sedentary fathers' or 'Exercised fathers'. Animals from this second group were put into a physical activity program (40 mins of treadmill activity every day for 6 weeks) while the sedentary group was kept without access to treadmill or any physical activity. After 6 weeks, the performance of both groups was tested in different hippocampal-dependent tasks to collect behavioural data. Then they were all put into breed to obtain a second generation. The fathers were killed at 7 months and their hippocampus collected for RNA Sequencing. Then we tested the offspring of this first set of animals. We had two groups in this second generation: 'litters from sedentary fathers' and 'litters from exercised fathers'. We tested the litters in the same hippocampal-dependant tasks than fathers to collect behavioural data. Then were killed at 5.5 months and their hippocampus collected for RNA Sequencing. The two main goals of RNA Sequencing were: 1) to compare the levels of gene expression in hippocampus of exercised fathers with respect to sedentary ones; 2) to compare the levels of gene expression in hippocampus of litters from exercised fathers with respect to litters from sedentary ones.
Contributor(s) McGreevy KR, Tezanos P, Ferreiro-Villar I, Pallé A, Moreno M, Esteve-Codina A, Lamas-Toranzo I, Bermejo-Álvarez P, Fernández-Punzano J, Martín-Montalvo A, Montalbán R, Ferrón SR, Radford EJ, Fontán-Lozano Á, Trejo J
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Submission date Dec 10, 2018
Last update date Apr 16, 2019
Contact name José Luis Trejo
Organization name Instituto Cajal
Lab Adult Neurogenesis Group
Street address Avenida Doctor Arce 37
City Madrid
State/province Madrid
ZIP/Postal code 28002
Country Spain
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (23)
GSM3507416 s72
GSM3507417 s83
GSM3507418 s11
BioProject PRJNA509258
SRA SRP173252

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Supplementary file Size Download File type/resource
GSE123582_TREJO_01_C_SED_B_vs_C_RUN_B_without_outlier_results.xlsx 4.5 Mb (ftp)(http) XLSX
GSE123582_TREJO_01_PADRES_SED_B_vs_PADRES_RUN_B_without_outlier_results.xlsx 4.4 Mb (ftp)(http) XLSX
GSE123582_TREJO_01_without_outlier_norm_counts_CRIAS.xlsx 4.8 Mb (ftp)(http) XLSX
GSE123582_TREJO_01_without_outlier_norm_counts_PADRES.xlsx 3.0 Mb (ftp)(http) XLSX
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