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| Status |
Public on Dec 05, 2018 |
| Title |
Follicular helper T cells enhance autoimmunity through Ascl-2 in a murine model for Sjögren’s syndrome |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We investigated how Tfh cells contribute to the breakdown of peripheral immune tolerance and the formation of autoimmune lesions in a murine model of SS. Our results indicate a yet unreported mechanism of autoreactive response through Tfh cells in a SS model mouse, and it will be supportive for understanding the pathogenesis of autoimmunity.
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| Overall design |
Two-condition experiment, purified CD4+ CD25- T cells from spleen of non-thymectomied NFS/sld (Control) vs. purified CD4+ CD25- T cells from spleen of thymectomied NFS/sld (SS model).
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| Contributor(s) |
Otsuka K, Yamada A, Inagaki A, Arakaki R, Ushio A, Ishimaru N |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 04, 2018 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Naozumi Ishimaru |
| E-mail(s) |
ishimaru.n@tokushima-u.ac.jp
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| Phone |
0886337328
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| Organization name |
Tokushima University Graduate School
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| Department |
Oral Molecular Pathology
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| Street address |
Kuramoto
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| City |
Tokushima |
| ZIP/Postal code |
7708504 |
| Country |
Japan |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA508374 |
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