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Series GSE122795 Query DataSets for GSE122795
Status Public on May 09, 2019
Title Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To identify the molecular mechanisms responsible for enhanced atopic dermatitis (AD) pathogenesis upon Ets1 deficiency in CD4+ T cells, we compared transcriptome profile between CD4+ T cells from littermate control (LMC) and Ets1ΔdLck mice at the peak of AD progression by performing RNA-seq.
Overall design Skin-draining lymph nodes near sites of inflammation under AD were excised from LMC and Ets1ΔdLck mice and prepared into single cell suspensions. CD4+ T cells were purified by CD4+ negative selection method.
Contributor(s) Lee C, Im S
Citation(s) 30843878
Submission date Nov 21, 2018
Last update date May 09, 2019
Contact name Sin-Hyeog Im
Phone +82-54-279-2356
Organization name Institute for Basic Science
Department Academy of Immunology and Microbiology
Street address POSTECH Biotech Center Rm. 428-431, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Republic of Korea
City Pohang
State/province Gyeongsangbuk-do
ZIP/Postal code 37673
Country South Korea
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (6)
GSM3485520 Control 1
GSM3485521 Control 2
GSM3485522 Control 3
BioProject PRJNA506378
SRA SRP170017

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE122795_RAW.tar 1.5 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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