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Series GSE121893 Query DataSets for GSE121893
Status Public on Oct 21, 2019
Title Dissecting cell composition and cell-cell interaction network of human disease heart tissue by single-cell sequencing
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We studied the cell compositon of two types of human heart disease (coronary atherosclerotic heart disease and dilated cardiomyopathy) by single-cell sequencing. Distinct subgroups of cardiac muscle, fibroblast cell and endothelial cell were detected. We generated a cell-cell interaction network using specific expressed ligands and receptors of cells. And we also observed the change of interaction and cell transformation with age.
Overall design Extract cells from left ateria and ventricle of human heart tissue and conduct single-cell sequencing
Contributor(s) Wang L, Yu P, Li Z, Ren Z
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Submission date Oct 29, 2018
Last update date Oct 21, 2019
Contact name Li Wang
Organization name NIH
Street address 111 T.W. Alexander Dr
City Durham
ZIP/Postal code 27709
Country USA
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (8)
GSM3449613 C1
GSM3449614 C2
GSM3449615 D1
BioProject PRJNA498994
SRA SRP167084

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE121893_files.txt.gz 41.5 Kb (ftp)(http) TXT
GSE121893_human_heart_sc_info.txt.gz 295.1 Kb (ftp)(http) TXT
GSE121893_human_heart_sc_umi.csv.gz 16.0 Mb (ftp)(http) CSV
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