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Series GSE121467 Query DataSets for GSE121467
Status Public on Oct 25, 2018
Title Expression data from retinal pigment epithelium in pigmented and albino mouse embryos
Organism Mus musculus
Experiment type Expression profiling by array
Summary In mammalian albinism, disrupted melanogenesis in the retinal pigment epithelium (RPE) is associated with fewer retinal ganglion cells (RGCs) projecting ipsilaterally to the brain, resulting in numerous abnormalities in the retina and visual pathway, especially binocular vision.
To further understand the molecular link between disrupted RPE and a reduced ipsilateral RGC projection in albinism, we compared gene expression in the embryonic albino and pigmented mouse RPE.
 
Overall design Embryonic day (E) 13.5 mouse RPE was detached from the eyes. Three biological replicates were analyzed. For each biological replicate (pigmented and albino), RPE tissues of three - four littermate embryos were pooled.
 
Contributor(s) Iwai-Takekoshi L, Mason C
Citation(s) 30254141
NIH grant(s)
Grant ID Grant title Affiliation Name
R01 EY012736 Growth and Guidance of Retinal Axon Trustees of Columbia University in the City of New York Carol A. Mason
R01 EY015290 The role of the ciliary margin zone and Cyclin D2 in patterning the binocular projection Trustees of Columbia University in the City of New York Carol A. Mason
R21 EY023714 RPE-Neural Retina Interactions in the Developing Albino Eye Trustees of Columbia University in the City of New York Carol A. Mason
P30 EY019007 Core Facilities for Vision Research Trustees of Columbia University in the City of New York MICHAEL E. GOLDBERG
Submission date Oct 18, 2018
Last update date Feb 11, 2019
Contact name Lena Iwai-Takekoshi
E-mail(s) iwait@nig.ac.jp
Organization name Columbia University
Department Pathology and Cell Biology
Lab Carol Ann Mason
Street address 3227 Broadway, Room L3-043, Quad 3C
City New York
State/province NY
ZIP/Postal code 10027
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM3436795 albino at E13.5, biological rep1
GSM3436796 albino at E13.5, biological rep2
GSM3436797 albino at E13.5, biological rep3
Relations
BioProject PRJNA497407

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Supplementary file Size Download File type/resource
GSE121467_RAW.tar 20.4 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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