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Series GSE121083 Query DataSets for GSE121083
Status Public on Jan 15, 2019
Title Oligodendrocyte progenitor cells become regionally diverse and heterogeneous with age
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating oligodendrocytes during central nervous system (CNS) development, are the main proliferative cells in the adult brain. OPCs are conventionally considered a homogeneous population, particularly with respect to their electrophysiological properties, but this has been debated. We show, by using single-cell electrophysiological recordings, that OPCs start out as a homogeneous population, but become functionally heterogeneous, varying both within and between brain regions and with age. These electrophysiological changes in OPCs correlate with the differentiation potential of OPCs; thus, they may underlie the differentiational differences in OPCs between regions and likewise differentiation failure with age.
Overall design Total RNA profiles of oligodendrocyte precursor cells isolated from 3 to 4 wild-type mice at different time points, using SMARTer® Stranded Total RNA-Seq Kit v2 - Pico Input Mammalian.
Contributor(s) Dietmann S, Evans KA, Kamen Y, Káradóttir RT
Citation(s) 30654924
Submission date Oct 10, 2018
Last update date Mar 19, 2019
Contact name Sabine Dietmann
Organization name Wellcome Trust/Medical Research Council Stem Cell Institute
Street address Tennis Court Road
City Cambridge
ZIP/Postal code CB2 1QR
Country United Kingdom
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (13)
GSM3425810 E16.ms1.
GSM3425811 E16.ms2.
GSM3425812 E16.ms3.
BioProject PRJNA495612
SRA SRP164927

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE121083_RAW.tar 30.8 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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