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| Status |
Public on Jun 18, 2008 |
| Title |
Pharmacological regulation of skeletal muscle gene expression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Exercise activates serine/threonine kinase AMPK and transcriptional factor PPARdelta that re-model metabolism and endurance capacity of skeletal muscle. Whether and how synthetic activation of these molecules regulated muscle gene signature is unknown.
We have conducted skeletal muscle microarrays from mice treated with AMPK agoinst (AICAR), PPARdelta agonist (GW1516) or the combination of the two drugs to investigate the individual and interactive effects of the two on muscle genes.
Keywords: Pharmacology study
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| Overall design |
C57Bl/6J mice were treated with Vehicle, AICAR, GW1516 and the combination of two drugs for 6 days, followed by collection of quadriceps for gene expression analysis.
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| Contributor(s) |
Narkar V, Evans R |
| Citation(s) |
18674809 |
| |
| Submission date |
Jun 16, 2008 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Ruth T Yu |
| Organization name |
Salk Institute
|
| Department |
Gene Expression Lab
|
| Lab |
Ronald Evans
|
| Street address |
10010 N Torrey Pines Rd
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92037 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE11805 |
PPARdelta ligand GW1516, AMPK agonist AICAR, and exercise training |
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| Relations |
| BioProject |
PRJNA109087 |
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