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Series GSE11791 Query DataSets for GSE11791
Status Public on Aug 21, 2008
Title Estrogen- and Myc-regulated genes in MCF-7 breast cancer cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Estrogen-responsive genes were identified by transcript profiling of estrogen-treated MCF-7 breast cancer cells.
The gene expression profile generated after estrogen treatment was compared with that following inducible expression of c-Myc or c-Zip (a deletion mutant of c-Myc that lacks the N-terminal transactivation domains) in clonal MCF-7 cell lines.

Keywords: Single time point
Overall design RNA was collected in three independent experiments, each including parental MCF-7 cells treated with 17b-estradiol (E2) or ethanol (EtOH), zinc-treated p∆MT-c-Myc cells, zinc-treated p∆MT-c-Zip cells and zinc-treated empty vector (p∆MT) cells. Cells were arrested for 48 h with 10 nM ICI 182780 and then treated for 6 h with either 100 nM E2 or ethanol vehicle, or 75 mM zinc for the stably transfected cell lines.
Contributor(s) Musgrove E
Citation(s) 18714337
Submission date Jun 16, 2008
Last update date Mar 25, 2019
Contact name Liz Musgrove
Phone +61 2 9295 8328
Fax +61 2 9295 8321
Organization name Garvan Institute of Medical Research
Department Cancer Research Program
Street address 384 Victoria Street, Darlinghurst
City Sydney
State/province NSW
ZIP/Postal code 2010
Country Australia
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (15)
GSM298353 MCF7_EtOH_rep1
GSM298354 MCF7_EtOH_rep2
GSM298355 MCF7_EtOH_rep3
BioProject PRJNA105991

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Supplementary file Size Download File type/resource
GSE11791_RAW.tar 66.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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