|
| Status |
Public on Jun 28, 2018 |
| Title |
Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4 |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
In this study, we establish a mechanism in which mutant p53 cooperates with MLL4 to regulate aberrant enhancer activity and tumor promoting gene expression in response to chronic TNF-a signaling.
|
| |
|
| Overall design |
Examination of MLL4 binding in SW480 colon cancer cells as well as mutant p53 binding and H3K4me1 accumulation in control (LacZ) or p53 depleted SW480 cells following treatment with TNF-a for 16 hr.
|
| |
|
| Contributor(s) |
Rahnamoun H, Hong J, Sun Z, Lee J, Lu H, Lauberth SM |
| Citation(s) |
29954944 |
| |
| Submission date |
Jun 19, 2018 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Shannon M Lauberth |
| E-mail(s) |
slauberth@ucsd.edu
|
| Organization name |
UCSD
|
| Department |
Biological Sciences
|
| Lab |
Lauberth Lab
|
| Street address |
9500 Gilman Drive #0322, Bonner Hall 3202
|
| City |
San Diego |
| State/province |
California |
| ZIP/Postal code |
92093 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (5)
|
|
| Relations |
| BioProject |
PRJNA476701 |
| SRA |
SRP150830 |
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