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Series GSE115598 Query DataSets for GSE115598
Status Public on Jun 11, 2018
Title Regulatory network controlling tumor-promoting inflammation in human cancers [RNA-seq]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Using an inducible, inflammatory model of breast cellular transformation, we describe the transcriptional regulatory network mediated by STAT3, NF-kB, and AP-1 factors on a genomic scale. These regulators form transcriptional complexes that directly regulate the expression of hundreds of genes in oncogenic pathways, such as cell proliferation, metastasis, angiogenesis, apoptosis and metabolism, via a positive feedback loop. This inflammatory feedback loop and associated network, which function to various extents in many types of cancer cells and patient tumors, is the basis for an “inflammation” index that defines cancer types by functional criteria. The inflammation index is negatively correlated with expression of genes involved in DNA metabolism, and transformation is associated with genome instability. Inflammatory tumors are preferentially associated with infiltration immune cells that might be recruited to the site of the tumor via inflammatory molecules produced by the cancer cells.
 
Overall design RNA-seq during MCF10A-ER-Src cell transformation and after STAT3, NF-kb, JUN, JUNB and FOS knockouts
 
Contributor(s) Lizhi H, Zhe J, Struhl K
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Submission date Jun 11, 2018
Last update date Mar 27, 2019
Contact name Zhe Ji
E-mail(s) zhe.ji@northwestern.edu
Organization name Northwestern University
Street address 303 E Superior St, Lurie 6-107
City Chicago
State/province ILLINOIS
ZIP/Postal code 60611
Country USA
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (9)
GSM3184667 Ctrl_EtOH
GSM3184668 Ctrl_TAM
GSM3184669 JUNBKO_TAM
This SubSeries is part of SuperSeries:
GSE115599 Regulatory network controlling tumor-promoting inflammation in human cancers
Relations
BioProject PRJNA475554
SRA SRP150227

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE115598_norm.gene.exp.batch1.txt.gz 251.9 Kb (ftp)(http) TXT
GSE115598_norm.gene.exp.batch2.txt.gz 177.3 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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