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Series GSE115597 Query DataSets for GSE115597
Status Public on Jun 11, 2018
Title Regulatory network controlling tumor-promoting inflammation in human cancers [ChIP-seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Using an inducible, inflammatory model of breast cellular transformation, we describe the transcriptional regulatory network mediated by STAT3, NF-kB, and AP-1 factors on a genomic scale. These regulators form transcriptional complexes that directly regulate the expression of hundreds of genes in oncogenic pathways, such as cell proliferation, metastasis, angiogenesis, apoptosis and metabolism, via a positive feedback loop. This inflammatory feedback loop and associated network, which function to various extents in many types of cancer cells and patient tumors, is the basis for an “inflammation” index that defines cancer types by functional criteria. The inflammation index is negatively correlated with expression of genes involved in DNA metabolism, and transformation is associated with genome instability. Inflammatory tumors are preferentially associated with infiltration immune cells that might be recruited to the site of the tumor via inflammatory molecules produced by the cancer cells.
Overall design ChIP-seq for STAT3, NF-kb, JUN, JUNB and FOS before and after MCF10A-ER-Src cell transformation
Contributor(s) Fleming JD, Zhe J, Struhl K
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Submission date Jun 11, 2018
Last update date Dec 03, 2018
Contact name Zhe Ji
Organization name Northwestern University
Street address 303 E Superior St, Lurie 6-107
City Chicago
State/province ILLINOIS
ZIP/Postal code 60611
Country USA
Platforms (1)
GPL9115 Illumina Genome Analyzer II (Homo sapiens)
Samples (10)
GSM3184657 FOS_EtOH_ChIPseq
GSM3184658 FOS_TAM_ChIPseq
GSM3184659 JUNB_EtOH_ChIPseq
This SubSeries is part of SuperSeries:
GSE115599 Regulatory network controlling tumor-promoting inflammation in human cancers
BioProject PRJNA475553
SRA SRP150228

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE115597_RAW.tar 22.0 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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