GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE115314 Query DataSets for GSE115314
Status Public on Feb 18, 2019
Title The lineage-specific transcriptional regulator, CDX2, navigates a dynamic chromatin landscape to control distinct stages of intestinal development
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary Important lineage regulators, such as the intestinal lineage regulator CDX2, can function over the timespan of intestinal development. The consequences of CDX2 knockout in the embryo versus in the adult are quite distinct. The data below provide a rationale for these divergent transcription factor functions in distinct developmental contexts, with unique binding patterns of CDX2 observed via ChIP-seq and unique gene regulatory targets defined via RNA-seq. The dynamic gene regulatory program controlled by CDX2 is conserved in mice and humans.
Overall design CDX2 ChIP-seq and RNA-seq experiments were conducted at various stages of mouse or human iPSC-derived tissues or primary adult human tissues.
Contributor(s) Verzi M, Kumar N, Chen L
Citation(s) 30745430
Submission date Jun 04, 2018
Last update date Feb 20, 2019
Contact name Michael P Verzi
Organization name Rutgers, the State University of New Jersey
Department Genetics
Lab Verzi
Street address 145 Bevier Road
City Piscataway
State/province NJ
ZIP/Postal code 08854
Country USA
Platforms (2)
GPL21626 NextSeq 550 (Mus musculus)
GPL21697 NextSeq 550 (Homo sapiens)
Samples (21)
GSM3175484 Cdx2 ChIP-seq mouse E13.5 rep1
GSM3175485 Cdx2 ChIP-seq mouse E13.5 rep2
GSM3175486 Cdx2 ChIP-seq mouse E16.5 rep1
BioProject PRJNA474516
SRA SRP149724

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE115314_E12.5_WTvsCdx2KO_cuffnorm_genes.fpkm_table.txt.gz 349.7 Kb (ftp)(http) TXT
GSE115314_RAW.tar 2.6 Gb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap