NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Reviewer access | Sign OutHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE11512 Query DataSets for GSE11512
Status Public on Mar 10, 2009
Title Gene expression changes during primate postnatal brain development
Platform organism Homo sapiens
Sample organisms Macaca mulatta; Pan troglodytes; Homo sapiens
Experiment type Expression profiling by array
Summary In development, timing is of the utmost importance, and the timing of various developmental processes are often changed during evolution. During human evolution sexual maturation has been delayed relative to other primates and this may have played a critical role for both the increase of human brain size and the rise of human-specific cognitive traits .
We measured the timing of gene expression changes in the brains of humans, chimpanzees, and rhesus macaques throughout postnatal development.
 
Overall design Human, chimpanzee and rhesus macaque post-mortem brain samples from the dorsolateral prefrontal cortex region were collected. The caudate nucleus region was additionally sampled for humans. The age ranges of the individuals in all three species covered the respective species' postnatal maturation period from infancy to young adulthood. RNA extracted from the dissected tissue was hybridized to Affymetrix® U133-plus2.0 GeneChip® arrays.
Web link http://www.picb.ac.cn/Comparative/
 
Contributor(s) Somel M, Franz H, Giger T, Nickel B, Bahn S, Webster MJ, Weickert CS, Lachmann M, Pääbo S, Khaitovich P
Citation(s) 19307592
Submission date May 20, 2008
Last update date Mar 19, 2012
Contact name Mehmet Somel
E-mail(s) somel@eva.mpg.de
Phone +49-(0)341-3550-530
Fax +49-(0)341-3550-555
Organization name Max Planck Institute for Evolutionary Anthropology
Department Evolutionary Genetics
Street address Deutscher Platz 6
City Leipzig
ZIP/Postal code D-04103
Country Germany
 
Platforms (1)
GPL6879 Affymetrix GeneChip Human Genome U133 Plus 2.0 Array [HGU133Plus2_Hs_ENSG (v11.0.1) CDF]
Samples (80)
GSM289913 Human dorsolateral prefrontal cortex 0.1 years old, rep1
GSM289914 Human dorsolateral prefrontal cortex 0.1 years old, rep2
GSM289915 Human dorsolateral prefrontal cortex 0.2 years old, rep3
Relations
BioProject PRJNA106343

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE11512_HGU133Plus2_Hs_ENSG_11.0.0_h18c2r2umask_maskedprobes.tsv.gz 1.0 Mb (ftp)(http) TSV
GSE11512_RAW.tar 600.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap