|
| Status |
Public on Nov 16, 2018 |
| Title |
Kidney compartment specific eQTL studies highlight causal genes and pathways for renal disease development |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Expression quantitative trait loci (eQTL) analyses were conducted separately on the glomerular and tubular portions of healthy human kidney samples obtained from subjects of European descent.
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| |
|
| Overall design |
We aimed to define genotype driven gene expression changes in the glomerular and tubular compartments of human kidneys, identifying genetic variants (eVariants) that influence the expression of genes (eGenes). Later, we integrated this information with genotype and phenotype association studies (GWAS) to identify genes for which expression in the kidney shows differences in patients with GWAS variants.
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| |
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| Contributor(s) |
Qiu C, Susztak K |
| Citation(s) |
30275566, 31167971, 31451708, 34426578 |
| Submission date |
May 30, 2018 |
| Last update date |
Sep 29, 2021 |
| Contact name |
Chengxiang Qiu |
| E-mail(s) |
cxqiu@uw.edu
|
| Organization name |
University of Washington
|
| Department |
Genome Sciences
|
| Lab |
Jay Shendure
|
| Street address |
William H. Foege Hall, 3720 15th Ave NE
|
| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98195 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (20)
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| Relations |
| BioProject |
PRJNA473790 |
| SRA |
SRP149347 |
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