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Series GSE11484 Query DataSets for GSE11484
Status Public on Nov 15, 2008
Title Gene expression analysis of ctrl_islets versus VhlhKO_islets
Organism Mus musculus
Experiment type Expression profiling by array
Summary Understanding the nature of the various glucose-derived signals for insulin secretion (both triggering and amplifying) is essential for gaining insight into the functional failure of the beta-cells in diabetes and the development of drugs for correcting this problem. The beta-cells uniquely couple changes in cellular metabolism to electrical activity and thus insulin release. In mice, beta-cell specific deletion of the von Hippel-Lindau (VHL) tumor suppressor protein leads to the activation of a HIF transcription program that includes genes involved in glycolysis, suppression of mitochondrial activity and lactate production. This reprogramming of cellular metabolism results in abnormal insulin secretion properties.
Overall design Three batches of isolated islets from each genotype where used for RNA isolation and Affymetrix measurements.
Contributor(s) Zehetner J, Danzer CF, Krek W
Citation(s) 19056893
Submission date May 16, 2008
Last update date Feb 11, 2019
Contact name Jens Zehetner
Organization name ETH Zurich
Department Cell Biology
Street address Schafmattstrasse 18
City Zurich
State/province Zurich
ZIP/Postal code 8093
Country Switzerland
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (6)
GSM289098 mouse_islets_ctrl_01
GSM289160 mouse_islets_ctrl_02
GSM289161 mouse_islets_ctrl_03
BioProject PRJNA106409

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE11484_RAW.tar 39.7 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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